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- $Unique_ID{BRK00260}
- $Pretitle{}
- $Title{What is Zollinger-Ellison Syndrome?}
- $Subject{Zollinger-Ellison stomach ulcers tumors Ill Defined Symptoms symptom
- Digestive ulcer diarrhea peptic tumor pancreas duodenum gastrinoma secretion
- secretions gastrin gastric acid Z-E Arteriography H2 blocker surgical
- operation surgery surgeries operations H2 blockers block acid formation}
- $Volume{N-10, I-10}
- $Log{
- Anatomy of the Pancreas*0016601.scf}
-
- Copyright (c) 1991-92,1993 Tribune Media Services, Inc.
-
-
- What is Zollinger-Ellison Syndrome?
-
-
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-
- QUESTION: At first it was thought my husband was suffering from a stomach
- ulcer. Now the doctor informs us that he has a disease with the strange name
- of Zollinger-Ellison, but that the treatment is the same. What does this all
- mean?
-
- ------------------------------------------------------------------------------
-
- ANSWER: The strange name comes from the discoverers of this syndrome, which
- indeed closely resembles a stomach ulcer. It develops rapidly with pain that
- is difficult to control, ulcer formation and diarrhea as its principle
- symptoms; but the ulcers are found to be in different locations in the stomach
- than are usually found with simple peptic ulcers. Even with tests performed
- correctly, including x-rays and endoscopy (looking at the stomach through a
- special telescope-like tube) this syndrome cannot be distinguished from
- ordinary ulcer in more than 50% of the patients. Its cause is a tumor of the
- pancreas or wall of the duodenum called a gastrinoma. These tumors result in
- the increased secretion of gastrin into the blood which stimulates the cells
- of the stomach to produce massive amounts of gastric acid. If a sensitive
- blood test for gastrin shows that there are increased amounts, Z-E syndrome
- can be diagnosed. The tumors, however, are hard to find. Arteriography,
- which may show circulation to the tumor, is the best test but discovers them
- in less than one case in two. Sometimes ultrasound can be used, but it too
- detects tumors in only 20-30% of the patients. The good news is that the same
- medications that block acid formation in peptic ulcer (called H2 blockers)
- work very well for Z-E. However since a surgical cure is possible, an
- exploratory operation should be considered to locate and remove the tumor.
-
- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
-
-